薛玉花博士、教授、 博士生导师

厦门市引进海外高层次留学人才

福建省高层次引进人才

个人简介：

薛玉花博士主要从事真核生物基因转录调控与重大疾病发生的分子机制研究以及相关靶向药物的开发。在美国加州大学伯克利分校从事博士后研究。自2011年9月在厦门大学药学院从事教学科研工作，现为厦门大学药学院教授。主持国家自然科学基金3项（2013-2015年；2017-2020年；2025-2028年），国家卫生部基金1项（2013-2015年）、福建省级项目4项（2012-2014年；2016-2019年，2016-2018年；2024-2026年）、厦门市级项目1项（2025-2027）、与企业合作项目3项（2014- 2015年；2015-2017年；2022-2023年）、厦门大学“校长基金”2项（2016-2018年；2019年），以项目骨干参加国家重大研发专项2项（2018-2022年；2020-2025年）。已获得发明专利授权7项；担任福建省药理学会理事、中国老年医学学会慢病防治与管理分会委员、厦门市青少年科学教育顾问、多种期刊审稿人。

主要研究方向：

1. 基因转录延伸调控分子机制研究

2. 基因转录与肿瘤、艾滋病、眼表疾病的发病机制及其药物开发

论文：（#第一作者，*通讯作者）

1. Kai Fan, Nuo Dong, Meichai Fang, Zixun Xiang, Lan Zheng, Mengyuan Wang, Yukuan Shi, Gang Tan*, Cheng Li*, Yuhua Xue*. Ozone exposure affects corneal epithelial fate by promoting mtDNA leakage and cGAS/STING activation [J].Journal of Hazardous Materials,465 (2024) 133219.  

2. Mingtao Ao# , Jun Wu# , Yin Cao , Yaohui He , Yuxiang Zhang , Xiang Gao ,Yuhua Xue∗, Meijuan Fang∗, Zhen Wu∗. The synthesis of PROTAC molecule and new target KAT6A identification of CDK9 inhibitor iCDK9 [J]. Chinese Chemical Letters, 2023, 34(4): 107741.

3. Honghua Kang#, Yi Han#, Mengyi Jin, Lan Zheng, Zhen Liu, Yuhua Xue∗, Zuguo Liu∗, Cheng Li∗. Decellularized squid mantle scaffolds as tissue-engineered corneal stroma for promoting corneal regeneration. Bioengineering & Translational Medicine. 2023;e10531

4. Kai Fan, Lixue Yu, Yuehuang Wu, Lan Zheng, Xiuqin Yang, Jingwei Lin, Mengyuan Wang, Yingyue Ye, Ruimiao Lin, Quancheng Chen, Zeyu Liu, Yuhua Xue*, Jingjing Xie*, Cheng Li*, Clickable corneal neovascularization therapy with ROS-responsive polydopamine silica nanoparticles loaded with fenofibrate, Materials &Design,Volume 235,2023,112412,ISSN 0264-1275

5. Yi Han, Lan Zheng, Yixin Wang, Kai Fan, Shujia Guo, Honghua Kang, Jingwei Lin,Yuhua Xue*, Zuguo Liu*, Cheng Li*. Corneal stromal filler injection of gelatin-based photocurable hydrogels formaintaining the corneal thickness and reconstruction of corneal stroma. Composites Part B, 266 (2023) 111004.

6. Cong Wang, Chunjing Chen, Zhenrui Pan, Yaohui He, Zhanming Zhang, Rongdiao Liu, Yuhua Xue*, Qiang Zhou, Xiang Gao*. Quantitative Proteomics of the CDK9 Interactome Reveals a Function of the HSP90-CDC37-P-TEFb Complex for BETi-Induced HIV-1 Latency Reactivation. J Proteome Res. 2023 Sep 1;22(9):2880-2889.

7. Guoliang Wang, Lina Xu, Ruize Shi, Yingyue Ye, Baihui Zeng, Xiuqin Yang, Zeyu Liu, Zhen Liu, Shurong Wang, Yuhua Xue*, Cheng Li*. Organotypic culture model of mouse meibomian gland as a screening platform for risk factors related to meibomian gland dysfunction. Ocul Surf. 2023 Oct;30:73-84.

8. Zhou Xiaoping#, Wang Guoliang#, An Xiaoya, Wu Jun, Fan Kai, Xu Lina, Li Cheng, Xue Yuhua*. Polystyrene microplastic particles: In vivo and in vitro ocular surface toxicity assessment [J]. Environmental Pollution 2022, 303(119126.

9. Wang Yanzi#, Kang Honghua, Jin Mengyi, Wang Guoliang, Ma Weifang, Liu Zhen, Xue Yuhua*, Li Cheng*. Phenotypic and Transcriptomics Analyses Reveal Underlying Mechanisms in a Mouse Model of Corneal Bee Sting [J]. Toxins (Basel), 2022, 14(7):

10. Wang Cong#, Wang Huiru, Pan Zhenrui, Wu Jun, Guo Yafei, Zhang Jing, Xiang Zixun, Lu Wei*, Xue Yuhua*. Polyphenol Extracts from Grape Seeds and Apple Can Reactivate Latent HIV-1 Transcription through Promoting P-TEFb Release from 7SK snRNP [J]. Disease Markers, 2022, 2022(6055347.

11. Wang Cong#, Lu Huasong, Liu Xiangzhong, Gao Xiang, Tian Wenjing, Chen Haifeng*, Xue Yuhua*, Zhou Qiang*. A natural product targets BRD4 to inhibit phase separation and gene transcription [J]. iScience, 2022, 25(1): 103719.

12. Zong Rong-Rong#, Zhu Fei-Feng, Han Wei, Wang Yi-Xin, Wang Guo-Liang, Wang Yan-Zi, Mao Yu-Bin, Guan Tian-Jun, Liu Zu-Guo, Xue Yu-Hua*, Li Cheng*. Tear dynamics testing and quantitative proteomics analysis in patients with chronic renal failure [J]. Journal of Proteomics 2021, 248(104351.

13. Wu Jun#, Hu Hongyu#, Ao Mingtao#, Cui Zhenzhen, Zhou Xiaoping, Qin Jingbo, Guo Yafei, Chen Jingwei*, Xue Yuhua*, Fang Meijuan*. Design, synthesis, and biological evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-Indole-2-Carbohydrazide derivatives: the methuosis inducer 12A as a Novel and selective anticancer agent [J]. Journal of Enzyme Inhibition and Medicinal Chemistry, 2021, 36(1): 1436-53.

14. Wu Jun#, Guo Yafei, Chen Jun, Hu Sangsang, Sun Ke, Hu Hongyu*, Fang Meijuan*, Xue Yuhua*. Synthesis and Antiproliferative Activity of New Thiosemicarboxamide Derivatives [J]. Chemistry Biodiversity, 2021, 18(12): e2100671.

15. Wang Guoliang#, An Xiaoya, Zhou Xiaoping, Jin Mengyi, Wang Xuemei, Zong Rongrong, Liu Zhen, Liu Zuguo, Xue Yuhua*, Li Cheng*. Real-time confocal microscopy imaging of corneal cytoarchitectural changes induced by different stresses [J]. Experimental Eye Research 2021, 210(108706.

16. An Xiaoya#, Wang Guoliang, Jin Mengyi, Zhou Xiaoping, Gao Shubin, Chen Jingyao, Reinach Peter S, Liu Zuguo, Xue Yuhua*, Li Cheng*. Novel Cell Culture Paradigm Prolongs Mouse Corneal Epithelial Cell Proliferative Activity in vitro and in vivo [J]. Frontiers in Cell and Developmental Biology, 2021, 9(675998.

17. Yang Shuiyuan#, Tian Wenjing , Pan Zhenrui , Lin Ting , Wang Guanghui , Zhou Qiang , Xue Yuhua* , Haifeng Chen*. POLYPHENOLS FROM Polygonum cuspidatum REACTIVATE LATENT HIV [J]. Chemistry of Natural Compounds, 2020, 56(2): 318-22.

18. Wang Guoliang#, Chen Pei, Wang Yanzi, Wang Yixin, Reinach Peter S, Xue Yuhua*, Liu Zuguo*, Li Cheng*. Onion Epithelial Membrane Scaffolds Transfer Corneal Epithelial Layers in Reconstruction Surgery [J]. Advanced Healthcare Materials, 2020, 9(14): e2000469.

19. Tang Dan#, Chen Chunjing, Liao Ga, Liu Jiaming, Liao Banghua, Huang Qingqing, Chen Qianqian, Zhao Jiahui, Jiang Hui, Duan Jinsong, Huang Jin, Wang Kunjie, Wang Jiawei, Zhou Cuiyan, Chu Wendan, Li Wenqi, Sun Bo, Li Zhonghan, Dai Lunzhi,, Fu Xianghui, Cheng Wei, Xue Yuhua*, Qi Shiqian*. Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription [J]. Cell Discovery, 2020, 6(7).

20. Liu Rongdiao#, Chen Chunjing#, Li Yun#, Huang Qingqing, Xue Yuhua*. ELL-associated factors EAF1/2 negatively regulate HIV-1 transcription through inhibition of Super Elongation Complex formation [J]. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2020, 1863(5): 194508.

21. Li Baicun#, Zhu Feifeng, He Fengming, Huang Qingqing, Liu Xiaoguang, Wu Tong, Zhao Taige, Qiu Yingkun, Wu Zhen, Xue Yuhua*, Fang Meijuan*. Synthesis and biological evaluations of N'-substituted methylene-4-(quinoline-4-amino) benzoylhydrazides as potential anti-hepatoma agents [J]. Bioorganic Chemistry, 2020, 96(103592).

22. Jin Mengyi#, Wang Yanzi, Wang Yixin, Li Yunpeng, Wang Guoliang, Liu Xuezhi, Xue Yuhua*, Liu Zuguo, Li Cheng*. Protective Effects Oncorneal Endothelium During Intracameral Irrigation Using N-(2)-l-alanyl-l-Glutamine [J]. Frontiers in Cell and Developmental Biology, 2020, 11(369).

23. Hu Hongyu#, Wu Jun, Ao Mingtao, Zhou Xiaoping, Li Boqun, Cui Zhenzhen, Wu Tong, Wang Lijuan, Xue Yuhua*, Wu Zhen*, Fang Meijuan*. Design, synthesis and biological evaluation of methylenehydrazine-1-carboxamide derivatives with (5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole scaffold: Novel potential CDK9 inhibitors [J]. Bioorganic Chemistry, 2020, 102(104064).

24. Wang Guoliang#, Xue Yuhua#, Wang Yanzi, Dong Fei, Shen Mei, Zong Rongrong, Liu Zuguo, Li Cheng*. The role of autophagy in the pathogenesis of exposure keratitis [J]. Journal of Cellular and Molecular Medicine, 2019, 23(6): 4217-28.

25. Ao Mingtao#, Pan Zhenrui, Qian Yuqing, Tang Bowen, Feng Zeming, Fang Hua, Wu Zhen, Chen Jingwei*, Xue Yuhua*, Fang Meijuan*. Design, synthesis, and biological evaluation of AV6 derivatives as novel dual reactivators of latent HIV-1 [J]. RSC Advances, 2018, 8(31): 17279-92.

26. Wu Jun#, Ao Ming-Tao, Shao Rui, Wang Hui-Ru, Yu Diao, Fang Mei-Juan, Gao Xiang, Wu Zhen*, Zhou Qiang*, Xue Yu-Hua*. A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter [J]. Scientific Reports, 2017, 7(1): 10657.

27. Wang Cong#, Yang Shuiyuan#, Lu Huasong, You Hongchao, Ni Man, Shan Wenjun, Lin Ting, Gao Xiang, Chen Haifeng, Zhou Qiang, Xue Yuhua*. A Natural Product from Polygonum cuspidatum Sieb. Et Zucc. Promotes Tat-Dependent HIV Latency Reversal through Triggering P-TEFb's Release from 7SK snRNP [J]. PloS One, 2015, 10(11): e0142739.

28. Lu Huasong#, Xue Yuhua#, Yu Guoying K, Arias Carolina, Lin Julie, Fong Susan, Faure Michel, Weisburd Ben, Ji Xiaodan, Mercier Alexandre, Sutton James, Luo Kunxin, Gao Zhenhai*, Zhou Qiang*. Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism [J]. Elife, 2015, 4(e06535.

29. Liu Rong-Diao#, Wu Jun#, Shao Rui, Xue Yu-Hua*. Mechanism and factors that control HIV-1 transcription and latency activation [J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2014, 15(5): 455-65.

30. Xue Yuhua, Yang Zhiyuan, Chen Ruichuan, Zhou Qiang*. A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP [J]. Nucleic Acids Research, 2010, 38(2): 360-9.

招聘：本实验室诚招博士后，博士及硕士研究生（长期有效）。

联系方式：

地址：福建省厦门市翔安区翔安南路厦门大学药学院439室

邮编：361102  

Email: xueyuhua@xmu.edu.cn