报告题目：“Mechanism of Retinal Ganglion Cells Pathogenesis in Glaucoma”
报告人：Dorota Skowronska-Krawczyk 博士

Associate Project Scientist, University of California, San Diego

报告简介：Glaucoma is a blinding neurodegenerative disease, whose risk factors include elevated intraocular pressure (IOP), age, and genetics. Glaucoma is characterized by accelerated and progressive retinal ganglion cell (RGC) death. Despite decades of research, the mechanism of RGC death in glaucoma is still unknown. Here, we demonstrate that the genetic effect of the SIX6 risk variant is enhanced by another major POAG risk gene, p16INK4a (cyclin-dependent kinase in-hibitor 2A, isoform INK4a). We further show that the upregulation of homozygous SIX6 risk alleles leads to an increase in p16INK4a expression, with subsequent cellular senescence, as evidenced in a mouse model of elevated IOP and in human POAG eyes. Our data indicate that SIX6 and/or IOP promote POAG by directly increasing p16INK4a expression, leading to RGC senescence in adult human retinas.
讲座时间：4月13日上午10:00
讲座地点：药学院 426学术报告厅
邀请人：刘文